Restore Windows 10 to a Previous Working State. Uninstall the latest update from Advanced Startup Options. Go Back to a Previous Windows Version (Build). Create the missing Desktop folder from Advanced Startup Options. Create the missing Desktop folder from the Windows GUI. So, before troubleshooting the problem, make sure that all the available updates are installed and also restart your PC (2-3 times) to complete the installation. Suggestion: The 'C:\Windows\system32\config\systemprofile\Desktop is unavailable' error, commonly appears because the Windows update installation isn't completed yet, or it is not completed successfully. How to FIX Windows 10 Error: C:\Windows\system32\config\systemprofile\Desktop is unavailable. If the location still can't be found, it might have been moved or deleted.' If the location is on a network, make sure you’re connected to the network or Internet, and then try again. If the location is on this PC, make sure the device or drive is connected or the disc is inserted, and then try again.
The following error may appear after updating Windows 10: 'C:\Windows\system32\config\systemprofile\Desktop is unavailable.